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July 20, 2026Blood Cancer JournalOpen Access

Detailed immunophenotypic and genetic characterization of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies

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This research aims to characterize the immunophenotypic and genetic profiles of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies.
Utilized next-generation flow cytometry to identify and purify bone marrow clonal plasma cells and B-cells from 25 asymptomatic individuals.
Conducted molecular analysis using next-generation sequencing on the purified cells.
Classified cases based on IgM vs non-IgM phenotypes for detailed profiling.
IgM-MGUS cases showed WM-like phenotypes with MYD88 p.L265P and/or CXCR4 mutations.
Non-IgM MGUS and smoldering MM demonstrated a MM-like phenotype, often with t(11;14) genetic drivers and unrelated cB-cells.
RUNX1 variants were found in clonal plasma cells from WM-like cases, indicating RUNX1's role in plasma cell differentiation.

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Implication

Randomized trial investigates immunophenotypic and genetic profiles of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies, highlighting diagnostic potentials.

Cite This Study

Pérez‐Escurza et al. (2026) studied this question.

synapsesocial.com/papers/6a5dbab88bd453d3397abcd3 https://doi.org/10.1038/s41408-026-01579-8

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Implication

Randomized trial investigates immunophenotypic and genetic profiles of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies, highlighting diagnostic potentials.

Detailed immunophenotypic and genetic characterization of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies

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Discussion

Implication

Cite This Study

Detailed immunophenotypic and genetic characterization of bone marrow clonal plasma cells and B-cells in early-stage monoclonal gammopathies

Key Points

Discussion

Implication

Cite This Study

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