Why the study?
Does the ACE2/Ang(1-7)/Mas axis protect pancreatic β cell function and survival in the setting of a high-fat diet or palmitate exposure?
Does the ACE2/Ang(1-7)/Mas axis protect pancreatic β cell function and survival in the setting of a high-fat diet or palmitate exposure?
The ACE2/Ang(1-7)/Mas axis protects pancreatic β cell function by improving islet microvascular endothelial cell function, suggesting a potential therapeutic target for diabetes.
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ACE2/Ang(1-7) effects on β-cell survival remain preliminary; leaves open therapeutic potential in human diabetes and requires prospective trials.
Lu et al. (2014) studied this question.
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