Why the study?
Does dilute pilocarpine detect early diabetic autonomic neuropathy in diabetic patients?
Does dilute pilocarpine detect early diabetic autonomic neuropathy in diabetic patients?
Pupillary denervation hypersensitivity to dilute pilocarpine is an early marker of diabetic autonomic neuropathy, preceding cardiovascular autonomic changes.
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May support early DAN screening via pilocarpine in diabetes clinics; hypothesis-generating and requires prospective validation before practice change.
Mary R. Cahill (2001) studied this question.
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