Population
Cellular models investigating TDP-43 and stress granules
Comparison
TDP-43 depletion or mutation (R361S, D169G) vs Wild-type TDP-43 or presence of TDP-43
Design
Preclinical
Authors
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TDP-43 stress granule regulation in mutants is hypothesis-generating; leaves open whether this pathway offers human therapeutic targets.
TDP-43 plays a central role in the cellular stress response by regulating stress granule dynamics, a function disrupted by specific disease-associated mutations.
McDonald et al. (2011) studied this question.
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