Key result
Endomyocardial biopsy reveals structural abnormalities in 100% of Brugada syndrome patients with normal noninvasive imaging.
Why the study?
Structural alterations in patients with Brugada syndrome are not detected by noninvasive evaluation, and the relationship with SCN5A mutations is unclear.
Does endomyocardial biopsy detect structural alterations in patients with the clinical phenotype of Brugada syndrome?
Does endomyocardial biopsy detect structural alterations in patients with the clinical phenotype of Brugada syndrome?
Endomyocardial biopsy reveals underlying structural alterations in patients with Brugada syndrome despite normal noninvasive evaluations, suggesting a histological substrate for the arrhythmias.
Supports histological substrate in Brugada syndrome; hypothesis-generating and should not change practice.
Despite an apparently normal heart at noninvasive evaluation, endomyocardial biopsy detected structural alterations in all 18 patients with Brugada syndrome. Mutations in the SCN5A gene, identified in 4 of the 18 patients, may have induced concealed structural abnormalities of myocardiocytes that accounted for paroxysmal arrhythmic manifestations.
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Frustaci et al. (2005) studied this question. Endomyocardial biopsy detected structural alterations in all 18 patients with Brugada syndrome despite apparently normal hearts on noninvasive evaluation.
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