In vitro study demonstrates antiprotozoal activity of novel thienopyrimidine sulphonamide hybrids against parasitic strains, indicating their potential as targeted therapeutic agents.
A series of hybrid compounds containing the thienopyrimidine scaffold with sulphonamide piperazine skeleton were synthesized and evaluated against K1 strain of Plasmodium falciparum and the HM1:1MSS strain of Entamoeba histolytica, respectively
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Zaidi et al. (2016) studied this question.
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