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October 11, 2010Proceedings of the National Academy of Sciences

Human oral, gut, and plaque microbiota in patients with atherosclerosis

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Authors

OKOmry KorenBar-Ilan UniversityASAymé SporInstitut National de la Recherche AgronomiqueJFJenny FelinUniversity of Gothenburg

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Implication

Observational study reveals oral and gut bacteria in atherosclerotic plaques, indicating microbial links to cardiovascular disease markers.

Key Points

  • To profile the microbial composition of atherosclerotic plaques and assess whether bacteria from the oral cavity or gut correlate with atherosclerosis markers in humans.
  • Quantified bacterial DNA in atherosclerotic plaque samples using qPCR and assessed correlation with plaque leukocyte counts.
  • Profiled bacterial diversity across atherosclerotic plaque, oral, and gut samples from 15 patients with atherosclerosis and oral and gut samples from healthy controls using 454 pyrosequencing of 16S rRNA genes.
  • Bacterial DNA was detected in atherosclerotic plaques and correlated quantitatively with plaque leukocyte levels.
  • Chryseomonas was identified in all plaque samples, while Veillonella and Streptococcus appeared in the majority; combined plaque levels of Veillonella and Streptococcus correlated with their oral abundance.
  • Multiple bacterial phylotypes were shared between plaques and matching oral or gut samples within individuals, and distinct oral and gut taxa correlated with plasma cholesterol concentrations.

Cite This Study

Koren et al. (2010) studied this question.

synapsesocial.com/papers/69dbb8d1cebd5668188358c2https://doi.org/10.1073/pnas.1011383107
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