Why the study?
Improving knowledge of the mechanisms linking obesity to insulin resistance is fundamental to recommend targeted follow-up and treatment in obese children and adolescents.
This review highlights the pathways involved in the development of insulin resistance in obese children and adolescents to guide targeted follow-up and treatment.
Does not support practice changes in obese youth; extends mechanistic insights but leaves open prospective validation.
The aim of this review is to present an updated frame and new insights of the numerous pathways involved in the development of insulin resistance in obese patients, focusing on the peculiarities of children and adolescents. Improving the knowledge of mechanisms through which obesity leads to insulin resistance is fundamental in order to recommend particular follow-up and possible treatment to specific categories of obese children and adolescents.
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Tagi et al. (2020) studied this question.
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