Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Population
Hepatitis E virus nonstructural polyprotein and other positive-strand RNA viruses
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports revised alpha-like virus taxonomy; leaves open experimental validation of domain conservation and evolution.
Structured PICO
P
Population
Hepatitis E virus (HEV) nonstructural polyprotein and other positive-strand RNA viruses (rubella virus [RubV] and beet necrotic yellow vein virus [BNYVV])
I
Intervention
Computer-assisted sequence comparison and domain analysis
O
Outcome
Identification of putative functional domains and phylogenetic grouping
Computer-assisted analysis identifies conserved functional domains among HEV, RubV, and BNYVV, suggesting they form a distinct monophyletic group of positive-strand RNA viruses.
Cite This Study
Koonin et al. (1992) studied this question.