Why the study?
Does ALK-rearrangement-positive status increase the risk of arterial and venous thromboembolism in patients with non-small cell lung cancer?
Does ALK-rearrangement-positive status increase the risk of arterial and venous thromboembolism in patients with non-small cell lung cancer?
Answers are grounded in this paper and cite their sources.
ALK-rearranged NSCLC is associated with a higher risk of venous thromboembolism compared to non-ALK-rearranged NSCLC, suggesting a potential need to evaluate thromboprophylaxis in this population.
In this study, we observed a higher VTE risk, but not ATE risk, in patients with ALK-rearranged NSCLC relative to those without ALK rearrangement. Prospective studies are warranted to evaluate thromboprophylaxis in ALK-positive NSCLC.
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Icht et al. (2023) studied this question.
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