What question did this study set out to answer?

To review the physiological actions of estrogens and examine how signaling through estrogen receptors contributes to the pathogenesis and progression of diverse human diseases.

March 1, 2006Journal of Clinical InvestigationOpen Access

Estrogen receptors and human disease

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Authors

BDBonnie J. DerooWestern University

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Implication

Review reveals widespread estrogen receptor involvement across multiple human diseases, highlighting therapeutic targeting opportunities.

Key Points

To review the physiological actions of estrogens and examine how signaling through estrogen receptors contributes to the pathogenesis and progression of diverse human diseases.
Narrative synthesis of biomedical literature on estrogen and estrogen receptor signaling mechanisms in human physiology.
Evaluation of receptor-mediated disease mechanisms across oncologic, metabolic, skeletal, autoimmune, and cardiovascular disorders.
Estrogen receptor activity plays a central role in driving or exacerbating various malignancies, including breast, ovarian, colorectal, prostate, and endometrial cancers.
Receptor dysfunction contributes significantly to non-malignant pathologies, including osteoporosis, neurodegeneration, cardiovascular disease, insulin resistance, lupus erythematosus, and obesity.
Estrogen receptors serve as established and emerging therapeutic targets to modulate disease development and clinical severity.

Cite This Study

Bonnie J. Deroo (2006) studied this question.

synapsesocial.com/papers/69dbc75c50e1971baba3caa3 https://doi.org/10.1172/jci27987

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Estrogen receptors and human disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Estrogen receptors and human disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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