Key result
TRAIL promotes endothelial cell survival and proliferation via Akt and ERK without inducing inflammation.
Why the study?
The role of the TRAIL/TRAIL-R system in endothelial cell physiology, particularly its effect on survival and proliferation without inducing inflammation, was not fully understood.
Key points are not available for this paper at this time.
Population
Primary human vascular endothelial cells
Comparison
TRAIL exposure vs no TRAIL exposure
Design
Experimental study
May support endothelial viability without inflammation in vitro; leaves open translation to cardiovascular therapies.
The ability of TRAIL to promote the survival/proliferation of endothelial cells without inducing NF-kappaB activation and inflammatory markers suggests that the TRAIL/TRAIL-R system plays an important role in endothelial cell physiology.
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Secchiero et al. (2003) studied this question. TRAIL promotes survival and proliferation of human vascular endothelial cells via Akt and ERK pathways without inducing NF-kappaB activation or inflammatory markers.
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