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June 25, 2007British Journal of PharmacologyOpen Access

PSNCBAM‐1, a novel allosteric antagonist at cannabinoid CB₁ receptors with hypophagic effects in rats

James G. Horswill Utsav Bali Sama Naziyah Shaaban John F Keily P Jeevaratnam Adam J. Babbs Christine Reynet Pidevich In

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Abstract

PSNCBAM-1 exerted its effects through selective allosteric modulation of the CB1 receptor. The acute effects on food intake and body weight induced in rats provide a first report of in vivo activity for an allosteric CB1 receptor antagonist.

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Horswill et al. (2007) studied this question.

synapsesocial.com/papers/69dbcb69c9a120f055a3c962 https://doi.org/10.1038/sj.bjp.0707347

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