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January 1, 2009Human Reproduction UpdateOpen Access

Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis

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Why the study?

Are adiponectin levels lower in women with PCOS compared to non-PCOS controls?

Population

Women with polycystic ovary syndrome (PCOS)

Comparison

Assessment of adiponectin levels vs Non-PCOS controls

Design

Meta-analysis

Authors

KTKonstantinos A. ToulisBirmingham City UniversityDGDimitrios G. GoulisAristotle University of ThessalonikiDFDimitrios FarmakiotisBeth Israel Deaconess Medical Center

Discussion

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Implication

Adiponectin should not serve as a PCOS biomarker; confirms lower levels independent of BMI.

Structured PICO

Are adiponectin levels lower in women with PCOS compared to non-PCOS controls?

P
Population
Women with polycystic ovary syndrome (PCOS)
I
Intervention
Assessment of adiponectin levels
C
Comparator
Non-PCOS controls
O
Outcome
Adiponectin levelssurrogate

Total adiponectin levels are lower in PCOS due to insulin resistance but should not be used as a biomarker of PCOS severity.

Cite This Study

Toulis et al. (2009) studied this question.

synapsesocial.com/papers/69dbcc2278a3e0e288685a71https://doi.org/10.1093/humupd/dmp006
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome2006 · 578 citations
  2. 2Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls2006 · 132 citations
  3. 3Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study2007 · 89 citations