Are adiponectin levels lower in women with PCOS compared to non-PCOS controls?
Total adiponectin levels are lower in PCOS due to insulin resistance but should not be used as a biomarker of PCOS severity.
After controlling for BMI-related effects, adiponectin levels seem to be lower in women with PCOS compared with non-PCOS controls. Low levels of adiponectin in PCOS are probably related to IR but not to testosterone. Total adiponectin should not be used as a biomarker of PCOS severity. Further investigation is needed for HMW adiponectin levels in PCOS.
Toulis et al. (Thu,) studied this question.
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