What question did this study set out to answer?

To investigate whether heme oxygenase 1 (HO-1) regulates osteoclast formation and inflammatory bone destruction in cellular systems, animal models, and human disease.

October 18, 2005The FASEB Journal

Heme oxygenase 1 (HO‐1) regulates osteoclastogenesis and bone resorption

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To investigate whether heme oxygenase 1 (HO-1) regulates osteoclast formation and inflammatory bone destruction in cellular systems, animal models, and human disease.
Induced HO-1 in vitro using hemin to assess osteoclastogenesis, mature osteoclast function, and signaling intermediates including MAPK, c-fms, RANK, TRAF-6, and c-fos.
Evaluated bone loss in vivo using mouse models of LPS-driven bone loss and TNF-mediated inflammatory arthritis.
Analyzed HO-1 expression in synovial tissue from patients with rheumatoid arthritis and measured serum bilirubin levels in relation to joint damage.
Hemin-mediated HO-1 induction produced a significant dose-dependent inhibition of osteoclastogenesis by preventing precursor differentiation via MAPK, c-fms, RANK, TRAF-6, and c-fos down-regulation, without affecting mature osteoclasts.
HO-1 induction suppressed TNF-triggered osteoclast formation in vitro, inhibited LPS-driven bone loss in vivo, and attenuated joint destruction in TNF-mediated arthritis.
Synovial osteoclasts from rheumatoid arthritis patients lacked HO-1 expression, whereas serum levels of the HO-1 metabolite bilirubin were elevated in patients without structural bone damage.

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Implication

Preclinical study demonstrates that heme oxygenase 1 induction inhibits osteoclastogenesis and inflammatory bone loss, suggesting a protective role against arthritic joint destruction.

Cite This Study

Zwerina et al. (2005) studied this question.

synapsesocial.com/papers/69dbccb87d378569a9835f8e https://doi.org/10.1096/fj.05-4278fje

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Implication

Preclinical study demonstrates that heme oxygenase 1 induction inhibits osteoclastogenesis and inflammatory bone loss, suggesting a protective role against arthritic joint destruction.

Heme oxygenase 1 (HO‐1) regulates osteoclastogenesis and bone resorption

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Discussion

Implication

Cite This Study

Heme oxygenase 1 (HO‐1) regulates osteoclastogenesis and bone resorption

Key Points

Discussion

Implication

Cite This Study

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