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Examines drivers of cardiovascular disease and persistent inflammation in people with HIV, highlighting unclear mechanisms and the impact of biological and social disparities.
Mechanistic studies into the drivers of chronic inflammation in PWH are ongoing and may aid in tailoring effective therapeutic strategies that can reduce ASCVD risk in this population. Focus should also include factors that lead to persistent disparities in HIV care and comorbidities, including sex as a biological factor and social determinants of health. It remains unclear whether ASCVD progression in HIV is driven by unique mediators (HIV itself, ART, immunodeficiency), or if it is an accelerated version of disease progression seen in the general population.
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Dirajlal‐Fargo et al. (2022) studied this question.
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