Shows that MitoQ perfusion reduces ischemia-reperfusion injury in a murine heart transplant model, indicating its potential to limit donor graft damage.
IR after heart transplantation results in mitochondrial oxidative damage that is potentiated by cold ischemia. Supplementing donor graft perfusion with the anti-oxidant MitoQ before transplantation should be studied further to reduce IR-related free radical production, the innate immune response to IR injury, and subsequent donor cardiac injury.
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Dare et al. (2015) studied this question.
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