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IR after heart transplantation results in mitochondrial oxidative damage that is potentiated by cold ischemia. Supplementing donor graft perfusion with the anti-oxidant MitoQ before transplantation should be studied further to reduce IR-related free radical production, the innate immune response to IR injury, and subsequent donor cardiac injury.
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Dare et al. (Sat,) studied this question.
synapsesocial.com/papers/69dbd2915b363cdf1c836006 — DOI: https://doi.org/10.1016/j.healun.2015.05.007
Anna Dare
St. Michael's Hospital
Angela Logan
University of Cambridge
Tracy A. Prime
University of Cambridge
The Journal of Heart and Lung Transplantation
University of Cambridge
Medical Research Council
National Institute for Health Research
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