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We report the synthesis of [¹⁸F]arylCF₃ and [¹⁸F]arylCHF₂ derivatives from arylCF₂Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [¹⁸F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce ¹⁸F-incorporation under very mild conditions.
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Gouverneur et al. (2015) studied this question.
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