Population
Patients with atrial fibrillation and experimental models of lone atrial fibrillation
Design
Review
Authors
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AF remodeling may represent adaptive survival rather than pure pathology; leaves open whether targeting dedifferentiation alters progression in long-standing cases.
Structural remodeling in atrial fibrillation represents an adaptive mechanism of programmed cell survival through cellular dedifferentiation, though prolonged duration or underlying pathology can lead to degeneration.
Victor L. Thijssen (2001) studied this question.
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