May 1, 1985Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

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Population

Scale model of the human carotid bifurcation and carotid bifurcations obtained from cadavers

Design

Preclinical

Authors

DKDavid N. KuVascular Medicine DGDon P. GiddensCross-Cutting Cardiology CZChristopher K. ZarinsVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Low shear stress correlates with intimal thickening in animal models; hypothesis-generating for human atherogenesis mechanisms.

Structured PICO

Population

Scale model of the human carotid bifurcation and carotid bifurcations obtained from cadavers

Intervention

Measurement of fluid velocities by laser Doppler velocimetry under pulsatile flow conditions

Outcome

Correlation between flow velocity/wall shear stress and intimal plaque thicknesssurrogate

This study demonstrates that atherosclerotic plaques in the carotid bifurcation tend to form in areas of low shear stress, and that marked oscillations in the direction of wall shear may enhance atherogenesis.

Cite This Study

Ku et al. (1985) studied this question.

synapsesocial.com/papers/69dbdb35f7e0c66ced836857 https://doi.org/10.1161/01.atv.5.3.293

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May 1, 1985Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

View Full Paper

Ask AI

Bookmark

Population

Scale model of the human carotid bifurcation and carotid bifurcations obtained from cadavers

Design

Preclinical

Authors

DKDavid N. KuVascular Medicine DGDon P. GiddensCross-Cutting Cardiology CZChristopher K. ZarinsVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Low shear stress correlates with intimal thickening in animal models; hypothesis-generating for human atherogenesis mechanisms.

Structured PICO

Population

Scale model of the human carotid bifurcation and carotid bifurcations obtained from cadavers

Intervention

Measurement of fluid velocities by laser Doppler velocimetry under pulsatile flow conditions

Outcome

Correlation between flow velocity/wall shear stress and intimal plaque thicknesssurrogate

Cite This Study

Ku et al. (1985) studied this question.

synapsesocial.com/papers/69dbdb35f7e0c66ced836857 https://doi.org/10.1161/01.atv.5.3.293

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