Does β-adrenergic receptor stimulation induce toxicity in STAT3-deficient cardiomyocytes?
β-adrenergic receptor stimulation induces toxic cellular alterations in STAT3-deficient cardiomyocytes, which may underlie dobutamine-induced irreversible heart failure progression in peripartum cardiomyopathy patients.
Iso impairs glucose uptake, induces energy depletion, oxidative stress, dysfunction, and death in STAT3-deficient cardiomyocytes mainly via β1-AR stimulation. These cellular alterations may underlie the dobutamine-induced irreversible heart failure progression in PPCM patients who frequently display reduced cardiac STAT3 expression.
Stapel et al. (Mon,) studied this question.