Animal study demonstrates robust healing of calvarial defects in rats using low-dose rhBMP-2 delivered via a mineralized hydrogel scaffold, indicating potential for efficient bone regeneration.
In situ mineralized PLGA/PSBMA scaffold enables high-efficiency sustained release of rhBMP-2 (only 1.7% within 35 days) and robust healing of critical-sized (5 mm) nonunion calvarial defects in rats with an ultralow dosage of rhBMP-2 (150 ng per scaffold).
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Liu et al. (2021) studied this question.
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