What question did this study set out to answer?

To outline the fundamental roles of the gut microbiota in host immunostasis and evaluate how microbial dysbiosis drives infectious, autoimmune, inflammatory, and malignant pathologies.

August 15, 2018SHILAP Revista de lepidopterologíaOpen Access

Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

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Authors

VLVeronica LazărUniversity of Bucharest LDLia-Mara DiţuUniversity of Bucharest GPGrațiela Grădișteanu PîrcălăbioruUniversity of Bucharest

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Implication

Literature review reveals extensive gut microbiota regulation of host immunity in human disease, highlighting probiotics and dietary interventions to counter dysbiosis.

Key Points

To outline the fundamental roles of the gut microbiota in host immunostasis and evaluate how microbial dysbiosis drives infectious, autoimmune, inflammatory, and malignant pathologies.
Synthesized biomedical literature investigating gut microbial community dynamics, host-microbiota immune crosstalk, and disease mechanisms.
Assessed the drivers of dysbiosis, including broad-spectrum antibiotics and diet, alongside restorative interventions involving probiotics.
Disruption of gut microbial equilibrium impairs immune tolerance and barrier integrity, predisposing hosts to infectious pathogens, hypersensitivity disorders, chronic inflammation, and carcinogenesis.
External perturbations such as antibiotic exposure and poor diet trigger dysbiosis, while targeted probiotic administration supports the restoration of protective eubiosis.

Cite This Study

Lazăr et al. (2018) studied this question.

synapsesocial.com/papers/69dbe1b640b636d1dda3c21d https://doi.org/10.3389/fimmu.2018.01830

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Implication

Literature review reveals extensive gut microbiota regulation of host immunity in human disease, highlighting probiotics and dietary interventions to counter dysbiosis.

Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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