What question did this study set out to answer?

To compare the efficacy of cefaclor and amoxicillin in clearing middle ear effusion and treating clinical symptoms in children with acute otitis media.

September 1, 1982The Pediatric Infectious Disease Journal

Duration of effusion after antibiotic treatment for acute otitis media

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Authors

EMEllen M. MandelUniversity of Pittsburgh CBCharles D. BluestoneBoston University HRHoward E. RocketteUniversity of Pittsburgh

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Implication

Randomized double-blind trial demonstrates faster middle ear effusion clearance with cefaclor than amoxicillin in pediatric acute otitis media, indicating short-term resolution advantages.

Key Points

To compare the efficacy of cefaclor and amoxicillin in clearing middle ear effusion and treating clinical symptoms in children with acute otitis media.
Conducted a double-blind randomized clinical trial at two sites enrolling 214 children (293 ears) with acute otitis media with effusion.
Children underwent unilateral or bilateral tympanocentesis and received a 14-day course of either amoxicillin or cefaclor, with evaluations at day 14 and day 42.
Symptomatic clinical failure occurred in 4 children in each antibiotic treatment group.
At day 14, 55.7% (59/106) of cefaclor patients were effusion-free compared with 41.2% (40/97) of amoxicillin patients (P = 0.05), and 64.2% (68/106) vs 44.3% (43/97) were effusion-free or improved (P = 0.01).
By day 42, effusion-free or improved rates were 68.9% in the cefaclor arm and 67.5% in the amoxicillin arm.

Cite This Study

Mandel et al. (1982) studied this question.

synapsesocial.com/papers/69dbe45840b636d1dda3c352 https://doi.org/10.1097/00006454-198209000-00006

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Implication

Randomized double-blind trial demonstrates faster middle ear effusion clearance with cefaclor than amoxicillin in pediatric acute otitis media, indicating short-term resolution advantages.

Duration of effusion after antibiotic treatment for acute otitis media

Discussion

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Implication

Key Points

Cite This Study

Duration of effusion after antibiotic treatment for acute otitis media

Discussion

Member takes

Implication

Key Points

Cite This Study

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