October 10, 2011European Heart Journal185 citationsOpen Access
View Full PaperOff-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials
Structured PICO
Does off-pump coronary artery bypass surgery reduce stroke compared to on-pump coronary artery bypass surgery?
P
Population
Patients undergoing coronary artery bypass surgery
I
Intervention
Off-pump coronary artery bypass surgery (OPCAB)
C
Comparator
On-pump coronary artery bypass surgery
O
Outcome
Strokehard clinical
Off-pump coronary artery bypass surgery appears to reduce the risk of stroke compared to on-pump surgery based on an updated meta-analysis of randomized trials.
Abstract
Our meta-analysis incorporating recent trials suggests that there appears to be a beneficial effect of OPCAB on stroke. Moreover, our meta-regression does not support the hypothesis that differences in study populations are responsible for the observed outcomes, although pooled individual patient-data would be better suited to confirm these findings.