Why the study?
Does hematopoietic deficiency of the long noncoding RNA MALAT1 promote atherosclerosis and plaque inflammation?
Does hematopoietic deficiency of the long noncoding RNA MALAT1 promote atherosclerosis and plaque inflammation?
Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis by enhancing the accumulation of hematopoietic cells.
No immediate clinical implications; leaves open MALAT1 modulation for human atherosclerosis.
Reduced levels of MALAT1 augment atherosclerotic lesion formation in mice and are associated with human atherosclerotic disease. The proatherosclerotic effects observed in Malat1-/- mice were mainly caused by enhanced accumulation of hematopoietic cells.
No takes yet. Share an insight, caveat, or question.
Cremer et al. (2019) studied this question.