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In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1⁺ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
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Audemard‐Verger et al. (2019) studied this question.
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