How Well Can Fragments Explore Accessed Chemical Space? A Case Study from Heat Shock Protein 90

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTHow Well Can Fragments Explore Accessed Chemical Space? A Case Study from Heat Shock Protein 90MiniperspectiveStephen D. Roughley† and Roderick E. Hubbard*†‡View Author Information† Vernalis (R&D) Ltd., Granta Park, Abington, Cambridge, CB21 6GB, U.K.‡ York Structural Biology Laboratory and Hull York Medical School, University of York, Heslington, York, YO10 5DD, U.K.Phone: +44-1223-895432. Fax: +44-1223-895556. E-mail: [email protected]Cite this: J. Med. Chem. 2011, 54, 12, 3989–4005Publication Date (Web):May 11, 2011Publication History Received25 March 2011Published online24 May 2011Published inissue 23 June 2011https://pubs.acs.org/doi/10.1021/jm200350ghttps://doi.org/10.1021/jm200350greview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views4794Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Chemical structure,Crystal structure,Inhibitors,Screening assays Get e-Alerts