What question did this study set out to answer?

To present a neurobiological model explaining heightened emotionality and variable turmoil during adolescence based on differential maturation of subcortical and cortical brain regions.

March 10, 2010Developmental PsychobiologyOpen Access

The storm and stress of adolescence: Insights from human imaging and mouse genetics

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To present a neurobiological model explaining heightened emotionality and variable turmoil during adolescence based on differential maturation of subcortical and cortical brain regions.
Synthesized behavioral and functional neuroimaging findings evaluating the development of emotion regulation in humans.
Integrated translational cross-species data, including mouse genetic models and human imaging, to evaluate how genetic and environmental factors modulate frontolimbic circuitry.
Adolescent emotional reactivity reflects a developmental mismatch where deep subcortical limbic regions (such as the amygdala) mature earlier than regulatory prefrontal cortical areas.
Environmental stressors exacerbate imbalances in amygdala-ventrofrontal circuitry, thereby increasing vulnerability to anxiety-related behaviors.
Genetic variations across both human and rodent models directly moderate frontolimbic neurodevelopment, accounting for individual differences in adolescent stress and resilience.

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Implication

Translational review demonstrates neurodevelopmental imbalance between limbic and prefrontal systems during adolescence, highlighting genetic and environmental modulators of emotional turmoil.

Cite This Study

Casey et al. (2010) studied this question.

synapsesocial.com/papers/69dbf48478a3e0e2886861bd https://doi.org/10.1002/dev.20447

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Implication

Translational review demonstrates neurodevelopmental imbalance between limbic and prefrontal systems during adolescence, highlighting genetic and environmental modulators of emotional turmoil.

The storm and stress of adolescence: Insights from human imaging and mouse genetics

Key Points

Discussion

Implication

Cite This Study

The storm and stress of adolescence: Insights from human imaging and mouse genetics

Key Points

Discussion

Implication

Cite This Study

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