What question did this study set out to answer?

To determine whether pre-existing cross-reactive memory T cells induced by endemic coronaviruses protect against SARS-CoV-2 infection upon exposure.

January 10, 2022Nature CommunicationsOpen Access

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

View Full Paper

Ask AI

Bookmark

Authors

RKRhia KunduKing's College London JNJanakan Sam NareanNIHR Imperial Biomedical Research Centre LWLulu WangHainan University

Discussion

Member takes

Implication

Cohort study shows cross-reactive non-spike memory T cells prevent SARS-CoV-2 infection in exposed contacts, suggesting non-spike targets improve vaccine design.

Key Points

To determine whether pre-existing cross-reactive memory T cells induced by endemic coronaviruses protect against SARS-CoV-2 infection upon exposure.
Evaluated 52 COVID-19 household contacts at early time points following SARS-CoV-2 exposure.
Used a dual-cytokine FLISpot assay on peripheral blood mononuclear cells to quantify memory T cells targeting spike, nucleocapsid, membrane, envelope, and ORF1 antigens cross-reactive with endemic coronaviruses.
Compared immune responses between contacts who remained PCR-negative (n=26) and those who became PCR-positive (n=26).
Contacts remaining PCR-negative had significantly higher frequencies of cross-reactive IL-2-secreting memory T cells (p = 0.0139) and nucleocapsid-specific T cells (p = 0.0355) compared to those who tested positive.
Spike-specific cross-reactive T-cell responses showed no statistically significant difference between infected and uninfected contacts, indicating a limited protective role for spike cross-reactivity alone.

Cite This Study

Kundu et al. (2022) studied this question.

synapsesocial.com/papers/69dbfc0c9e12f2ae65684090 https://doi.org/10.1038/s41467-021-27674-x

View Full Paper

Ask AI

Bookmark

Implication

Cohort study shows cross-reactive non-spike memory T cells prevent SARS-CoV-2 infection in exposed contacts, suggesting non-spike targets improve vaccine design.

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Discussion

Member takes

Implication

Key Points

Cite This Study

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider