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July 26, 2012European Heart JournalOpen Access

Coronary artery calcium for the prediction of mortality in young adults 75 years old

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Why the study?

Does coronary artery calcium scoring predict mortality in young adults <45 years old and elderly adults >75 years old?

Population

Young adults <45 years old and elderly adults >75 years old

Design

Cohort

Authors

RTRajesh Tota-MaharajJohns Hopkins University
Michael J. Blaha
Michael J. BlahaGeneral / Preventive / Lipids
John W. McEvoy
John W. McEvoyGeneral / Preventive / Lipids

Discussion

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Overview

May refine mortality risk assessment beyond age; extends CAC data to extremes but leaves practice change open.

Key Points

  • This research evaluates the efficacy of coronary artery calcium (CAC) in predicting mortality for young adults under 45 years and elderly adults over 75 years.
  • Assessed mortality risk (MR) in elderly persons with no CAC and younger persons with high CAC.
  • Compared mortality prediction using CAC in both age groups.
  • Elderly individuals with no CAC demonstrate a lower mortality risk compared to younger individuals with high CAC levels.

Structured PICO

Does coronary artery calcium scoring predict mortality in young adults <45 years old and elderly adults >75 years old?

P
Population
Young adults <45 years old and elderly adults >75 years old
I
Intervention
Coronary artery calcium (CAC) scoring
O
Outcome
Mortalityhard clinical

CAC scoring is a valuable predictor of mortality across age extremes, demonstrating that biological age (as measured by CAC) can trump chronological age in risk assessment.

Cite This Study

Tota-Maharaj et al. (2012) studied this question.

synapsesocial.com/papers/69dc0c377dffaba91f3749e1https://doi.org/10.1093/eurheartj/ehs230

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Artery Calcium to Predict All-Cause Mortality in Elderly Men and Women2008 · 269 citations
  2. 2Orthostatic Hypotension Predicts Mortality in Elderly Men1998 · 460 citations
  3. 3Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology2010 · 150 citations
  4. 4Impact of Coronary Artery Calcium Scanning on Coronary Risk Factors and Downstream Testing2011 · 455 citations
  5. 5The impact of the coronary collateral circulation on mortality: a meta-analysis2011 · 292 citations