August 1, 1994Circulation
Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies.
Population
Early lesions of "degenerative" valvular aortic stenosis
Design
Other
Authors
Discussion
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Member takes
Implication
Supports mechanistic studies of aortic stenosis inflammation; leaves open whether anti-atherosclerotic therapies alter progression.
Structured PICO
P
Population
Early lesions of "degenerative" valvular aortic stenosis
I
Intervention
Histological and immunohistochemical characterization
O
Outcome
Pathological characteristics of the early lesion
Early degenerative aortic stenosis lesions exhibit active inflammation, sharing some features with atherosclerosis but differing in mineralization and smooth muscle cell presence.
Cite This Study
Otto et al. (1994) studied this question.