What question did this study set out to answer?

To review the molecular mechanisms and signaling cascades through which extracellular and intracellular calcium regulate keratinocyte differentiation and epidermal barrier assembly.

July 1, 2012Expert Review of Endocrinology & MetabolismOpen Access

Calcium regulation of keratinocyte differentiation

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Authors

DBDaniel D. BikleUniversity of California, Riverside ZXZhongjian XieCentral South University CTChia‐Ling TuSan Francisco VA Medical Center

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Implication

Review outlines calcium signaling pathways in epidermal keratinocytes, highlighting how gradient-driven differentiation establishes the skin permeability barrier.

Key Points

To review the molecular mechanisms and signaling cascades through which extracellular and intracellular calcium regulate keratinocyte differentiation and epidermal barrier assembly.
Narrative synthesis of in vivo and in vitro research evaluating epidermal calcium gradients, receptor activation, and cell junction assembly.
An epidermal calcium gradient directs the sequential differentiation of keratinocytes across skin layers to generate the stratum corneum permeability barrier.
Extracellular calcium acts through calcium receptors and junctional complexes (desmosomes, adherens, and tight junctions) to activate kinases, phospholipases, and protein kinase C signaling.

Cite This Study

Bikle et al. (2012) studied this question.

synapsesocial.com/papers/69dc1386c5db605ba0751bb6 https://doi.org/10.1586/eem.12.34

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Implication

Review outlines calcium signaling pathways in epidermal keratinocytes, highlighting how gradient-driven differentiation establishes the skin permeability barrier.

Calcium regulation of keratinocyte differentiation

Discussion

Member takes

Implication

Key Points

Cite This Study

Calcium regulation of keratinocyte differentiation

Discussion

Member takes

Implication

Key Points

Cite This Study

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