Evaluation of plasma angiopoietin-2 and vascular endothelial growth factor in healthy dogs and dogs with systemic inflammatory response syndrome or sepsis

Figures

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  Figure 1. Plasma Ang‐2 concentrations in dogs (A) Comparison of plasma Ang‐2 concentrations among healthy control dogs (n = 18), dogs with SIRS (n = 32), and dogs with sepsis (n = 28). (B) Comparison of plasma Ang‐2 concentration between survivors (n = 35) and non‐survivors (n = 24). (C) Lack of a statistically significant correlation between plasma Ang‐2 concentrations and APPLEfast score in dogs with SIRS or sepsis. The central lines in the boxes represent the median values, and the top and bottom of the boxes represent the 75th and 25th percentiles, respectively. Data points were classified as outliers if they were more than 1.5 times the interquartile range above the third quartile or below the first quartile. Abbreviations: Ang‐2, angiopoietin‐2; APPLEfast score: acute patient physiologic and laboratory evaluation score (five‐variable disease severity model based on glucose, albumin, mentation score, platelet count, and lactate); SIRS: systemic inflammatory response syndrome

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  Figure 2. Plasma VEGF concentrations in dogs (A) Comparison of plasma VEGF concentrations among healthy control dogs (n = 7), dogs with SIRS (n = 32), and dogs with sepsis (n = 28). (B) Comparison of plasma VEGF concentration between survivors (n = 26) and non‐survivors (n = 21). (C) Lack of a statistically significant correlation between plasma VEGF concentrations and APPLEfast score in dogs with SIRS or sepsis. The central lines in the boxes represent the median values, and the top and bottom of the boxes represent the 75th and 25th percentiles, respectively. Data points were classified as outliers if they were more than 1.5 times the interquartile range above the third quartile or below the first quartile. Cut‐off for lower limit of detection (LLD) was 15 pg/mL; 27 of 53 samples were below the LLD. Abbreviations: Ang‐2, angiopoietin‐2; APPLEfast score, acute patient physiologic and laboratory evaluation score (five‐variable disease severity model based on glucose, albumin, mentation score, platelet count, and lactate); SIRS: systemic inflammatory response syndrome; VEGF, vascular endothelial growth factor

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  Figure 3. Weak positive correlation between plasma concentrations of VEGF and Ang‐2 in dogs with SIRS and sepsis. Abbreviations: Ang‐2, angiopoietin‐2; SIRS: systemic inflammatory response syndrome; VEGF, vascular endothelial growth factor