Why the study?
Does diabetes mellitus increase the risk of incident dementia in APOEɛ4 carriers?
Does diabetes mellitus increase the risk of incident dementia in APOEɛ4 carriers?
Preventing diabetes and its complications may be a way to modify dementia risk in the vulnerable APOEɛ4 population.
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Suggests diabetes as modifiable dementia risk factor in APOEɛ4 carriers; extends meta-analytic evidence on gene-risk interactions but requires prospective validation.
Interventions to prevent co-morbid diabetes, and diabetes-related complications and neuropathological changes, may be one way of modifying dementia risk in the vulnerable ɛ4 population.
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Li et al. (2020) studied this question.
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