The Role of Prolactin in Bone Metastasis and Breast Cancer Cell–Mediated Osteoclast Differentiation

Ashley Sutherland; Amanda Forsyth; Yingying Cong; Laurel Grant; TzuHua Juan; Jae K. Lee; Alexander C. Klimowicz; Stephanie Petrillo; Jinghui Hu; Angela Chan; Florence Boutillon; Vincent Goffin; Cay Egan; Patricia A. Tang; Li Cai; Don Morris; Anthony Magliocco; Carrie S. Shemanko

doi:10.1093/jnci/djv338

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Abstract

Our evidence indicates that PRL-PRLR can escalate the impact of breast cancer on bone metastasis and that the presence of the PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.

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Sutherland et al. (2015) studied this question.

synapsesocial.com/papers/69dc21ec4ee46a2379b65103 https://doi.org/10.1093/jnci/djv338

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The Role of Prolactin in Bone Metastasis and Breast Cancer Cell–Mediated Osteoclast Differentiation

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Abstract

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The Role of Prolactin in Bone Metastasis and Breast Cancer Cell–Mediated Osteoclast Differentiation

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Abstract

Discussion

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