June 1, 2001Journal of Biological ChemistryOpen Access

Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer

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Why the study?

Does the expression of CaT-L correlate with prostate cancer malignancy?

Structured PICO

Does the expression of CaT-L correlate with prostate cancer malignancy?

Population

Human prostate cancer tissues (locally advanced, metastatic, androgen-insensitive), healthy prostate tissue, benign prostatic hyperplasia, normal placenta, exocrine pancreas, and salivary glands

Intervention

Cloning and functional expression of CaT-L channel

Comparator

Healthy prostate tissue and benign prostatic hyperplasia

Outcome

Expression levels of CaT-L channelsurrogate

The human CaT-L channel represents a novel marker for prostate cancer progression and a potential therapeutic target.

Discussion

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Implication

CaT-L may mark prostate cancer progression in models; leaves open validation as biomarker or target in humans.

Cite This Study

Wissenbach et al. (2001) studied this question.

synapsesocial.com/papers/69dc221bba5d4effc7751c75 https://doi.org/10.1074/jbc.m009895200

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Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer

Structured PICO

Discussion

Implication

Cite This Study

Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider