What question did this study set out to answer?

To build a comprehensive reference atlas that links molecular transcriptional signatures to histologically defined anatomical zones within human glioblastomas.

May 10, 2018Science

An anatomic transcriptional atlas of human glioblastoma

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To build a comprehensive reference atlas that links molecular transcriptional signatures to histologically defined anatomical zones within human glioblastomas.
Collaborative integration of histopathology and bioinformatic profiling to establish the open-access Ivy Glioblastoma Atlas.
Mapped spatial gene expression signatures to discrete, microscopically identified anatomical compartments of glioblastoma tumors alongside clinical data.
Constructed a high-resolution, freely accessible transcriptional atlas pairing regional glioblastoma anatomy with distinct molecular profiles.
Identified spatial transcriptional relationships that correlate anatomical tumor architecture with genomic and clinical characteristics to aid future diagnosis and targeted therapy development.

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Implication

Genomic mapping study uncovers spatially distinct transcriptional signatures across anatomical regions in human glioblastoma, highlighting targets for pathogenesis, diagnosis, and therapy.

Cite This Study

Puchalski et al. (2018) studied this question.

synapsesocial.com/papers/69dc2372ce788f95bfb6508c https://doi.org/10.1126/science.aaf2666

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Implication

Genomic mapping study uncovers spatially distinct transcriptional signatures across anatomical regions in human glioblastoma, highlighting targets for pathogenesis, diagnosis, and therapy.

An anatomic transcriptional atlas of human glioblastoma

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Discussion

Implication

Cite This Study

An anatomic transcriptional atlas of human glioblastoma

Key Points

Discussion

Implication

Cite This Study

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