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June 17, 1999New England Journal of Medicine

Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs

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Authors

MWM. Michael WolfeEmory UniversityDLDavid R. LichtensteinBoston UniversityGSGurkirpal SinghHealth Outcomes Solutions (United States)

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Implication

Reveals gastrointestinal toxicity induced by nonsteroidal antiinflammatory drugs, suggesting a need for safer alternatives.

Key Points

  • The aim is to explore the gastrointestinal toxicity associated with nonsteroidal antiinflammatory drugs (NSAIDs) like aspirin.
  • Historical analysis of aspirin synthesis and its introduction as the first NSAID
  • Review of literature documenting gastric mucosal damage from NSAIDs
  • Confirmed endoscopic evidence shows that aspirin can cause gastric mucosal damage.
  • Numerous studies corroborate the toxicity of aspirin and other NSAIDs.

Cite This Study

Wolfe et al. (1999) studied this question.

synapsesocial.com/papers/69dc23a4ea70a37eff955338https://doi.org/10.1056/nejm199906173402407
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs1995 · 1,060 citations
  2. 2A guideline for the treatment and prevention of NSAID-induced ulcers1998 · 279 citations
  3. 3Misoprostol Compared with Sucralfate in the Prevention of Nonsteroidal Anti-inflammatory Drug-induced Gastric Ulcer1991 · 167 citations
  4. 4Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs1993 · 297 citations