Population
Human cardiac titin complementary DNA
Design
Preclinical
Authors
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May refine models of diastolic stiffness; leaves open translation to human HFpEF therapies.
The complete sequencing of human cardiac titin reveals its structure as a 3-megadalton protein acting as two springs in series, providing a molecular explanation for muscle elasticity and resting tension.
Labeit et al. (1995) studied this question.
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