What question did this study set out to answer?

To identify molecular and histologic mechanisms of acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients with EGFR-mutant lung cancers.

March 7, 2013Clinical Cancer ResearchOpen Access

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR -Mutant Lung Cancers

View Full Paper

Ask AI

Bookmark

Authors

HYHelena A. YuMemorial Sloan Kettering Cancer Center MAMaria E. ArcilaNorthside Hospital NRNatasha RekhtmanMemorial Sloan Kettering Cancer Center

Discussion

Member takes

Implication

Cohort study reveals EGFR T790M as the primary resistance mechanism in EGFR-mutant lung cancers, highlighting diverse molecular pathways of acquired EGFR-TKI resistance.

Key Points

To identify molecular and histologic mechanisms of acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients with EGFR-mutant lung cancers.
Evaluated tumor specimens collected at the development of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers.
Profiled tumors for secondary mutations, gene amplifications, and histologic transformations.
EGFR T790M emerged as the most frequent mechanism of acquired resistance to EGFR-TKIs.
Alternative resistance mechanisms, including MET amplification, HER2 amplification, and small cell histologic transformation, occurred at lower frequencies.

Cite This Study

Yu et al. (2013) studied this question.

synapsesocial.com/papers/69dc31ec3080d3567e274700 https://doi.org/10.1158/1078-0432.ccr-12-2246

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals EGFR T790M as the primary resistance mechanism in EGFR-mutant lung cancers, highlighting diverse molecular pathways of acquired EGFR-TKI resistance.

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR -Mutant Lung Cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR -Mutant Lung Cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider