⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

May 20, 2019TransplantationOpen Access

MHC-mismatched Allotransplantation of Induced Pluripotent Stem Cell-derived Cardiomyocyte Sheets to Improve Cardiac Function in a Primate Ischemic Cardiomyopathy Model

Noriyuki Kashiyama Shigeru Miyagawa Satsuki Fukushima Takuji Kawamura Ai Kawamura Shohei Yoshida Seiko Eiraku Akima Harada Keiko Matsunaga Tadashi Watabe Köichi Toda Jun Hatazawa Yoshiki Sawa

View Full Paper

Ask AI

Bookmark

Share

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Abstract

Although MHC-homo-iPSCs are preferred to avoid immune rejection, MHC-mismatched iPSC-CMs can also induce comparable cardiac functional recovery at late follow-up, suggesting that MHC-mismatched iPSC-based cardiac regenerative therapy with immunosuppressants is a feasible option for treating heart failure in clinical settings.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kashiyama et al. (2019) studied this question.

synapsesocial.com/papers/69dc3226d50c49528a9f5413 https://doi.org/10.1097/tp.0000000000002765

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Transplantation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Is Superior to Somatic Stem Cell Therapy for Restoring Cardiac Function and Oxygen Consumption in a Porcine Model of Myocardial InfarctionRandomized Controlled Trial · 2018 · 102 citations
2Modulation of Alloimmune Responses by Interleukin-10 Prevents Rejection of Implanted Allogeneic Smooth Muscle Cells and Restores Postinfarction Ventricular Functionpreclinical · 2014 · 3 citations
3Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human PrimatesOriginal Research · 2016 · 145 citations
4Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman PrimateOriginal Research · 2013 · 272 citations
5MHC matching improves engraftment of iPSC-derived neurons in non-human primatesOriginal Research · 2017 · 243 citations
6Generation of Mouse Induced Pluripotent Stem Cells Without Viral VectorsOriginal Research · 2008 · 2,056 citations
7Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cellsOriginal Research · 2012 · 365 citations
8A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cellsOriginal Research · 2014 · 673 citations
9Urological Complications in Kidney Retransplanted Patients - A Single Centre Experience.Transplantation · 2014
10Mechanotransduction Reshapes Epithelial Fate in Lung Ischemia/Reperfusion Injury Through Piezo1-dependent Calcium SignalingTransplantation · 2026

More from Transplantation

More from The University of Osaka

More from National Cerebral and Cardiovascular Center