Why the study?
Does high-dose atorvastatin reduce major coronary events compared to usual-dose simvastatin in patients with previous myocardial infarction?
Population
Patients with previous myocardial infarction
Comparison
High-dose atorvastatin vs Usual-dose simvastatin
Design
RCT, Randomized
Authors
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High-dose atorvastatin does not reduce major coronary events versus usual-dose simvastatin post-MI; challenges routine statin intensification despite secondary benefits.
Does high-dose atorvastatin reduce major coronary events compared to usual-dose simvastatin in patients with previous myocardial infarction?
In patients with previous MI, high-dose atorvastatin did not significantly reduce major coronary events compared to usual-dose simvastatin, but did reduce nonfatal acute MI without increasing serious adverse reactions.
Terje R. Pedersen (2005) studied this question.
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