What question did this study set out to answer?

To outline the medicinal importance and structural roles of heteroatoms and heterocyclic frameworks in active pharmaceutical ingredients and excipients.

October 25, 2019SHILAP Revista de lepidopterologíaOpen Access

Heterocycles in Medicinal Chemistry

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Authors

JJJosef JampílekPalacký University Olomouc

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Implication

Narrative review reveals the structural significance of heteroatoms in active pharmaceutical ingredients, highlighting the value of heterocyclic frameworks in drug design.

Key Points

To outline the medicinal importance and structural roles of heteroatoms and heterocyclic frameworks in active pharmaceutical ingredients and excipients.
Examined chemical configurations of heteroatoms integrated within aliphatic chains and cyclic rings.
Evaluated the impact of isosteric and bioisosteric substitutions on the physical and biological characteristics of therapeutic agents.
Heteroatoms serve as critical structural components across diverse active pharmaceutical ingredients and inactive excipients.
Bioisosteric replacement of carbon frameworks with heterocycles provides equivalent functional significance while facilitating targeted optimization of drug properties.

Cite This Study

Josef Jampílek (2019) studied this question.

synapsesocial.com/papers/69dc33cd3080d3567e27490e https://doi.org/10.3390/molecules24213839

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Implication

Narrative review reveals the structural significance of heteroatoms in active pharmaceutical ingredients, highlighting the value of heterocyclic frameworks in drug design.

Heterocycles in Medicinal Chemistry

Discussion

Member takes

Implication

Key Points

Cite This Study

Heterocycles in Medicinal Chemistry

Discussion

Member takes

Implication

Key Points

Cite This Study

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