Baroreflex stimulation unmasks impaired cardiovagal responses in early-stage ALS, suggesting a potential therapeutic target to prevent early cardiovascular fatalities.
May inform autonomic monitoring in early ALS; leaves open whether baroreflex modulation alters cardiovascular outcomes.
In early-stage ALS patients, BRS might be normal at rest. Only baroreflex activation reveals impaired cardiovagal responses while sympathetic vasomotor control is preserved. Treatment to restore sympathetic-parasympathetic balance to the heart could prevent early cardiovascular fatalities in some ALS patients.
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Hilz et al. (2002) studied this question.
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