April 20, 2020Acta Pharmaceutica Sinica BOpen Access

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

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Why the study?

Specific viral protein-targeted therapeutics for COVID-19 are lacking, and the structural information of the potential drug target SARS-CoV-2 nucleocapsid protein remained unclear.

Structured PICO

Population

SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain

Intervention

Crystal structure determination (2.7 Å) and in vitro binding studies

Comparator

Other reported coronavirus nucleocapsid protein N-terminal domains (e.g., HCoV-OC43)

Outcome

Crystal structure, surface electrostatic potential characteristics, and RNA binding pocket identificationsurrogate

The 2.7 Å crystal structure of the SARS-CoV-2 nucleocapsid protein N-terminal domain reveals a unique RNA binding pocket, providing atomic resolution features to guide the design of novel targeted antiviral agents.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May guide nucleocapsid-targeted antiviral design; leaves open clinical translation from structural data alone.

Cite This Study

Kang et al. (2020) studied this question.

synapsesocial.com/papers/69dc462b3080d3567e274c84 https://doi.org/10.1016/j.apsb.2020.04.009

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Ask AI

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Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Structured PICO

Discussion

Implication

Cite This Study

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider