Spatial multiplexed protein profiling reveals H3K9me3 in endothelial cells as a novel therapeutic target to prevent pathological remodeling after cardiac ischemia-reperfusion injury.
We mapped the spatiotemporal heterogeneity of cellular phenotypes in the adult heart upon IRI, and uncovered H3K9me3 in endothelial cells as a potential therapeutic target for alleviating pathological remodeling of the heart following myocardial IRI.
Yao et al. (Tue,) studied this question.