August 1, 1997EndocrinologyOpen Access

Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1*

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Why the study?

Does bovine growth hormone injection increase cortical vascular density in older rats?

Population

Brown-Norway and Fisher 344/Brown-Norway rats at 5, 7, 13, 29, and 30 months of age

Design

Preclinical

Follow-up

35 days

Authors

WSWilliam E. SonntagUniversity of Oklahoma Health Sciences Center CLColleen D. LynchUniversity of Vermont PCPaula T. CooneyUniversity of North Carolina at Greensboro

Discussion

Member takes

Implication

GH-IGF-1 modulation may affect cerebral arteriolar density in aged rats; leaves open translation to human cerebrovascular aging.

Structured PICO

Does bovine growth hormone injection increase cortical vascular density in older rats?

Population

Brown-Norway and Fisher 344/Brown-Norway rats at 5, 7, 13, 29, and 30 months of age

Intervention

Bovine growth hormone (GH) 0.25 mg/kg, subcutaneous, twice daily for 35 days (in 30-month-old animals)

Outcome

Vascular density (number of vessels/cortical surface area) and plasma levels of IGF-1surrogate

The age-related decline in cerebral vascular density is correlated with decreased IGF-1 levels and can be partially reversed by growth hormone supplementation in older rats.

Cite This Study

Sonntag et al. (1997) studied this question.

synapsesocial.com/papers/69dc68facdb4abb1d7133364 https://doi.org/10.1210/endo.138.8.5330

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Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider