Key result
MIF inhibition stabilizes atherosclerotic plaques by clearing macrophages and increasing smooth muscle cells.
Why the study?
The effect of macrophage migration inhibitory factor blockade on the stabilization of atherosclerotic plaques after vascular injury was investigated.
Does blockade of Macrophage Migration Inhibitory Factor stabilize atherosclerotic plaques in Apolipoprotein E-deficient mice after vascular injury?
Does blockade of Macrophage Migration Inhibitory Factor stabilize atherosclerotic plaques in Apolipoprotein E-deficient mice after vascular injury?
Inhibition of macrophage migration inhibitory factor promotes plaque stabilization in a preclinical model of atherosclerosis.
MIF inhibition may stabilize experimental neointima; leaves open whether targeting endothelial MIF improves clinical outcomes.
Inhibition of MIF resulted in a shift in the cellular composition of neointimal plaques toward a stabilized phenotype with reduced macrophage/foam cell content and increased SMC content. This might be attributable to a reduction of monocyte recruitment mediated by endothelial MIF.
No takes yet. Share an insight, caveat, or question.
Schober et al. (2003) studied this question. Inhibition of macrophage migration inhibitory factor stabilized atherosclerotic plaques in apolipoprotein E-deficient mice by reducing macrophages and increasing smooth muscle cells.
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