Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes

281 subjects, including patients with acute myocardial infarction (n=41), acute coronary syndromes (n=126), clinical depression plus previous acute coronary syndrome within 6 months (n=64), and normal healthy controls (n=50).

Concentrations of established biomarkers of enhanced platelet/endothelial activation (Platelet factor 4, beta-thromboglobulin, platelet/endothelial cell adhesion molecule-1, P-selectin, thromboxane, prostacyclin, vascular cell adhesion molecule-1, and E-selectin) measured by enzyme-linked immunosorbent assay.surrogate